UNC-2025

Catalog No.: A15904

Dual MER/FLT3 inhibitor

UNC-2025

UNC-2025 Chemical Structure

CAS NO. 1429881-91-3

UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.

Availability: In stock

Package Price Qty
5 mg
$54.00
10 mg
$92.00
25 mg
$162.00
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Biological Activity

UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.
In vitro DMSO 88 mg/mL (184.62 mM)
Water Insoluble
Ethanol 53 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.98 mL 104.89 mL 209.78 mL
0.5 mM 4.2 mL 20.98 mL 41.96 mL
1 mM 2.1 mL 10.49 mL 20.98 mL
5 mM 0.42 mL 2.1 mL 4.2 mL

*The above data is based on the productmolecular weight 476.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15904
Actions Inhibitor
CAS No. 1429881-91-3
Formula C28H40N6O
M. Wt 476.7
Purity >98%
Synonyms UNC 2025, UNC-2025
SMILES CCCCNC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCN(CC5)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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