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Biological Activity
UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.
| In vitro | DMSO | 88 mg/mL (184.62 mM) | |
| Water | Insoluble | ||
| Ethanol | 53 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.98 mL | 104.89 mL | 209.78 mL |
| 0.5 mM | 4.2 mL | 20.98 mL | 41.96 mL |
| 1 mM | 2.1 mL | 10.49 mL | 20.98 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.2 mL |
*The above data is based on the productmolecular weight 476.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15904 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1429881-91-3 |
| Formula | C28H40N6O |
| M. Wt | 476.7 |
| Purity | >98% |
| Synonyms | UNC 2025, UNC-2025 |
| SMILES | CCCCNC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCN(CC5)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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