UNC1666 is an ATP-competitive dual-target inhibitor of the Mer and Flt3 tyrosine kinases, exhibiting potent inhibition with IC50 values of 0.55 nM and 0.69 nM, and Ki values of 0.16 nM and 0.67 nM, respectively. This compound effectively inhibits the kinase activities of Mer and Flt3, leading to decreased phosphorylation levels and suppression of downstream pro-survival signaling pathways such as Erk1/2, Akt, and Stat. Additionally, UNC1666 promotes apoptosis and reduces colony formation in acute myeloid leukemia cells, making it a valuable tool for research focused on this malignancy.
UNC1666 is an ATP-competitive dual-target inhibitor of the Mer and Flt3 tyrosine kinases, exhibiting potent inhibition with IC50 values of 0.55 nM and 0.69 nM, and Ki values of 0.16 nM and 0.67 nM, respectively. This compound effectively inhibits the kinase activities of Mer and Flt3, leading to decreased phosphorylation levels and suppression of downstream pro-survival signaling pathways such as Erk1/2, Akt, and Stat. Additionally, UNC1666 promotes apoptosis and reduces colony formation in acute myeloid leukemia cells, making it a valuable tool for research focused on this malignancy.
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