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Biological Activity
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.21 mL | 106.03 mL | 212.06 mL |
| 0.5 mM | 4.24 mL | 21.21 mL | 42.41 mL |
| 1 mM | 2.12 mL | 10.6 mL | 21.21 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
*The above data is based on the productmolecular weight 471.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18523 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1612782-86-1 |
| Formula | C24H34FN7O2 |
| M. Wt | 471.57 |
| Purity | >98% |
| Synonyms | UNC 2541, UNC-2541 |
| SMILES | O=C(C(C(NCCCC[[email protected]@H]1N)=N2)=CN=C2NCCCCCCNC1=O)NCC3=CC=C(F)C=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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