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Val-Ala-PABC-Exatecan trifluoroacetate

Catalog No.: A41464
Drug-Linker Conjugates for ADC
Val-Ala-PABC-Exatecan trifluoroacetate is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It comprises a cleavable Val-Ala-PABC linker and Exatecan, a potent topoisomerase I inhibitor. This reagent enables the synthesis of ADC molecules by facilitating targeted delivery and controlled release of the cytotoxic agent, making it suitable for advancing cancer research and therapeutic development.
Val-Ala-PABC-Exatecan trifluoroacetate 2928571-45-1 Drug-Linker Conjugates for ADC
Grouped product items
Size Price Stock Qty
5mg
$195.00
In stock
10mg
$325.00
In stock
25mg
$645.00
In stock
50mg
$1,015.00
In stock
100mg
$1,570.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVal-Ala-PABC-Exatecan trifluoroacetate is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It comprises a cleavable Val-Ala-PABC linker and Exatecan, a potent topoisomerase I inhibitor. This reagent enables the synthesis of ADC molecules by facilitating targeted delivery and controlled release of the cytotoxic agent, making it suitable for advancing cancer research and therapeutic development.
Product Information
Catalog NumA41464
FormulaC42H44F4N6O10
Molecular Weight868.83
CAS Number2928571-45-1
SMILESCC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)=O)=C4CN3C2=O)C)=O)O.OC(C(F)(F)F)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC