Val-Ala-PABC-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, featuring a cleavable Tesirine linker (Val-Ala-PABC) coupled with Exatecan, a potent topoisomerase I inhibitor. This conjugate facilitates targeted delivery of cytotoxic agents, making it suitable for the synthesis of various ADC molecules, such as Mal-PEGn-amide-va-Exatecan. Its ability to selectively release the active drug upon internalization enhances therapeutic efficacy against cancer cells.
Val-Ala-PABC-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, featuring a cleavable Tesirine linker (Val-Ala-PABC) coupled with Exatecan, a potent topoisomerase I inhibitor. This conjugate facilitates targeted delivery of cytotoxic agents, making it suitable for the synthesis of various ADC molecules, such as Mal-PEGn-amide-va-Exatecan. Its ability to selectively release the active drug upon internalization enhances therapeutic efficacy against cancer cells.
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