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Val-Ala-PABC-N(Mesylpropane)-Exatecan

Catalog No.: A41603
Drug-Linker Conjugates for ADC
Val-Ala-PABC-N(Mesylpropane)-Exatecan is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). This compound features Exatecan, a potent inhibitor of DNA topoisomerase I, linked via a cleavable Val-Ala-PABC-N(Mesylpropane) moiety. It is intended for research applications focused on targeted cancer therapies, enhancing the selectivity and efficacy of antitumor agents.
Val-Ala-PABC-N(Mesylpropane)-Exatecan 2842021-73-0 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVal-Ala-PABC-N(Mesylpropane)-Exatecan is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). This compound features Exatecan, a potent inhibitor of DNA topoisomerase I, linked via a cleavable Val-Ala-PABC-N(Mesylpropane) moiety. It is intended for research applications focused on targeted cancer therapies, enhancing the selectivity and efficacy of antitumor agents.
Product Information
Catalog NumA41603
FormulaC46H54FN7O12S
Molecular Weight948.02
CAS Number2842021-73-0
SMILESCC(C)[C@H](N)C(N[C@@H](C)C(NC(C=C1)=CC=C1COC(N(CCS(C)(=O)=O)COCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC