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Val-Cit-PAB-DEA-Dxd

Catalog No.: A41543
Drug-Linker Conjugates for ADC
Val-Cit-PAB-DEA-Dxd is a versatile drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound integrates a cleavable linker with the potent DNA topoisomerase I inhibitor Dxd, facilitating targeted delivery of the cytotoxic agent. Val-Cit-PAB-DEA-Dxd is suitable for synthesis of ADCs aimed at enhancing therapeutic efficacy in cancer research.
Val-Cit-PAB-DEA-Dxd 2964543-53-9 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVal-Cit-PAB-DEA-Dxd is a versatile drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound integrates a cleavable linker with the potent DNA topoisomerase I inhibitor Dxd, facilitating targeted delivery of the cytotoxic agent. Val-Cit-PAB-DEA-Dxd is suitable for synthesis of ADCs aimed at enhancing therapeutic efficacy in cancer research.
Product Information
Catalog NumA41543
FormulaC50H61FN10O12
Molecular Weight1013.08
CAS Number2964543-53-9
SMILESCC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N(C)CCN(C)C(OCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC