Val-Cit-PAB-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a DNA topoisomerase I inhibitor, DX-8951, linked via a cathepsin-cleavable linker, Val-Cit-PAB. Its primary mechanism involves targeted delivery of the cytotoxic agent to cancer cells, thereby enhancing therapeutic efficacy while minimizing systemic toxicity. Val-Cit-PAB-Exatecan is utilized in research focused on developing effective ADC therapies for various malignancies.
Val-Cit-PAB-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a DNA topoisomerase I inhibitor, DX-8951, linked via a cathepsin-cleavable linker, Val-Cit-PAB. Its primary mechanism involves targeted delivery of the cytotoxic agent to cancer cells, thereby enhancing therapeutic efficacy while minimizing systemic toxicity. Val-Cit-PAB-Exatecan is utilized in research focused on developing effective ADC therapies for various malignancies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
