VEGFR2-IN-2 (compound 6e) is a highly potent and selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), exhibiting an IC50 of 19.32 nM. It effectively targets VEGFR2-mediated signaling, which is critical for tumor angiogenesis, thereby inhibiting tumor growth and metastasis. VEGFR2-IN-2 is a valuable tool for research into anti-angiogenic therapies, particularly for cancers such as colorectal, breast, lung, and ovarian cancers, where VEGFR2-driven angiogenesis plays a significant role. Its high selectivity and potency make it suitable for studying VEGFR2-specific mechanisms in tumor progression and evaluating combination therapies with other targeted agents.
VEGFR2-IN-2 (compound 6e) is a highly potent and selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), exhibiting an IC50 of 19.32 nM. It effectively targets VEGFR2-mediated signaling, which is critical for tumor angiogenesis, thereby inhibiting tumor growth and metastasis. VEGFR2-IN-2 is a valuable tool for research into anti-angiogenic therapies, particularly for cancers such as colorectal, breast, lung, and ovarian cancers, where VEGFR2-driven angiogenesis plays a significant role. Its high selectivity and potency make it suitable for studying VEGFR2-specific mechanisms in tumor progression and evaluating combination therapies with other targeted agents.
Product Information
Catalog Num
A24169
Formula
C15H11BrN2O
Molecular Weight
315.16
CAS Number
737818-56-3
SMILES
BrC1=CC=C(COC2=C3C=CC=CC3=NC=N2)C=C1
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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