X-376

Catalog No.: A20971

ALK inhibitor

X-376

X-376 Chemical Structure

CAS NO. 1365267-27-1

X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). X-376 is a less potent inhibitor of MET (IC50=0.69 nM). X-376 displays potent anti-tumor activity.

Availability: In stock

Package Price Qty
2 mg
$50.00
5 mg
$99.00
10 mg
$193.00
50 mg
$567.00
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Biological Activity

X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). X-376 is a less potent inhibitor of MET (IC50=0.69 nM). X-376 displays potent anti-tumor activity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.27 mL 91.34 mL 182.68 mL
0.5 mM 3.65 mL 18.27 mL 36.54 mL
1 mM 1.83 mL 9.13 mL 18.27 mL
5 mM 0.37 mL 1.83 mL 3.65 mL

*The above data is based on the productmolecular weight 547.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20971
Actions Inhibitor
M. Wt 547.41
Formula C25H25Cl2FN6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1365267-27-1
Synonyms X376, X 376
SMILES O=C(C1=NN=C(N)C(O[[email protected]@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3

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