X-376

Catalog No.: A20971

ALK inhibitor

X-376

X-376 Chemical Structure

CAS NO. 1365267-27-1

X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). X-376 is a less potent inhibitor of MET (IC50=0.69 nM). X-376 displays potent anti-tumor activity.

Availability: In stock

Package Price Qty
2 mg

Regular Price: $50.00

Special Price $40.00

5 mg

Regular Price: $99.00

Special Price $79.20

10 mg

Regular Price: $193.00

Special Price $154.40

50 mg

Regular Price: $567.00

Special Price $453.60

Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). X-376 is a less potent inhibitor of MET (IC50=0.69 nM). X-376 displays potent anti-tumor activity.
In vitro DMSO 94 mg/mL (171.71 mM)
Water Insoluble
Ethanol 12 mg/mL (21.91 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.27 mL 91.34 mL 182.68 mL
0.5 mM 3.65 mL 18.27 mL 36.54 mL
1 mM 1.83 mL 9.13 mL 18.27 mL
5 mM 0.37 mL 1.83 mL 3.65 mL

*The above data is based on the productmolecular weight 547.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20971
Actions Inhibitor
CAS No. 1365267-27-1
Formula C25H25Cl2FN6O3
M. Wt 547.41
Purity >98%
Synonyms X376, X 376
SMILES O=C(C1=NN=C(N)C(O[[email protected]@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy X-376 | X-376 Supplier | purchase | cost | manufacturer | order | distributor | buy 1365267-27-1| 1365267-27-1 Supplier | purchase 1365267-27-1 | 1365267-27-1 cost | 1365267-27-1 manufacturer | order 1365267-27-1 | 1365267-27-1 distributor
Rewards