XL184 free base (Cabozantinib)

XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2.
Grouped product items
Product Name Price Stock Qty
XL184 free base 5mg
$45.00
In stock
XL184 free base 10mg
$65.00
In stock
XL184 free base 50mg
$80.00
In stock
XL184 free base 100mg
$110.00
In stock
XL184 free base 10mM * 1mL in DMSO
$50.00
In stock
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Adooq Products cited in reputable paper
Adooq's XL184 free base (Cabozantinib) has been cited by 4 publications
  • Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591
  • Jhe-Cyuan Guo, .et al. , Journal of Clinical Oncology, 2024, May 29
  • Feyza Oflaz, .et al. , Cumhuriyet Sci. J., 2023, 44(4): 650-655
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Biological Activity
    Discription XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2.
    Targets
    Target Value
    Product Information
    Catalog Num A10996
    Formula C28H24FN3O5
    Molecular Weight 501.5
    CAS Number 849217-68-1
    SMILES COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
    Synonyms BMS-907351
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 92 mg/mL (183.44 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.94 mL 99.7 mL 199.4 mL
    0.5 mM 3.99 mL 19.94 mL 39.88 mL
    1 mM 1.99 mL 9.97 mL 19.94 mL
    5 mM 0.4 mL 1.99 mL 3.99 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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