ZG-2686 is a selective HIF-2α agonist that exhibits potent activity with an EC50 of 0.25 µM. By binding to a distinct internal cavity of HIF-2α, it stabilizes the HIF-2α/β heterodimer through hydrogen bonds with structural water molecules, thereby enhancing transcriptional activity. This compound has demonstrated the capability to synergize with Vadadustat to upregulate HIF-2α-dependent EPO gene expression in both in vitro and in vivo models. ZG-2686 is valuable for research focusing on renal anemia mechanisms and potential therapeutic approaches.
ZG-2686 is a selective HIF-2α agonist that exhibits potent activity with an EC50 of 0.25 µM. By binding to a distinct internal cavity of HIF-2α, it stabilizes the HIF-2α/β heterodimer through hydrogen bonds with structural water molecules, thereby enhancing transcriptional activity. This compound has demonstrated the capability to synergize with Vadadustat to upregulate HIF-2α-dependent EPO gene expression in both in vitro and in vivo models. ZG-2686 is valuable for research focusing on renal anemia mechanisms and potential therapeutic approaches.
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