Zurletrectinib is a potent tyrosine kinase inhibitor that selectively targets TRK kinases (TRKA IC50 = 0.81 nM; TRKB IC50 = 0.145 nM; TRKC IC50 = 0.184 nM). Its enhanced binding affinity results in superior efficacy, especially against various resistance mutations (effectively targeting 13 out of 18 known mutations). This compound is particularly useful for research applications related to glioma and exploring TRK signaling pathways in tumor biology.
Zurletrectinib is a potent tyrosine kinase inhibitor that selectively targets TRK kinases (TRKA IC50 = 0.81 nM; TRKB IC50 = 0.145 nM; TRKC IC50 = 0.184 nM). Its enhanced binding affinity results in superior efficacy, especially against various resistance mutations (effectively targeting 13 out of 18 known mutations). This compound is particularly useful for research applications related to glioma and exploring TRK signaling pathways in tumor biology.
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