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AM 114

20S proteasome inhibitor

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Catalog No. A14922

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AM 114 10mg A14922-10

Regular Price: $60.00

Special Price: $48.00

AM 114 25mg A14922-25

Regular Price: $120.00

Special Price: $96.00

AM 114 50mg A14922-50

Regular Price: $200.00

Special Price: $160.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.

AM 114

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Chemical Information

Catalog Num A14922
Actions Inhibitor
M. Wt 377.01
Formula C20H21B2NO5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 856849-35-9
Synonyms N/A
SMILES code B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O
Chemical Name [4-[(Z)-[(5Z)-5-[(4-boronophenyl)methylidene]-1-methyl-4-oxopiperidin-3-ylidene]methyl]phenyl]boronic acid

Biological Activity

Description
AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.

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