Proteases

Items 1 to 50 of 319 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction
  1. VX-765 (Belnacasan)

    Catalog No. A10984
    Quick View
    Caspase-1/4 inhibitor
    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18. Learn More
  2. Z-VAD-FMK

    Catalog No. A12373
    Quick View
    Pan Caspase Inhibitor
    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo. Learn More
  3. Nivocasan (GS-9450)

    Catalog No. A14100
    Caspase inhibitor
    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. Learn More
  4. Z-DEVD-FMK

    Catalog No. A13503
    Quick View
    Caspase-3 Inhibitor
    Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor. Learn More
  5. Z-LEHD-FMK

    Catalog No. A14358
    Caspase-9 Inhibitor
    Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. Learn More
  6. Q-VD-OPh hydrate

    Catalog No. A14915
    Quick View
    Caspase inhibitor
    Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Learn More
  7. Z-WEHD-FMK

    Catalog No. A14916
    Caspase inhibitor
    Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. Learn More
  8. Caspase-3/7 Inhibitor I

    Catalog No. A14919
    Quick View
    Caspase-3/7 Inhibitor
    Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM). Learn More
  9. Ac-LEHD-AFC

    Catalog No. A15291
    Quick View
    Fluorogenic caspase substrate
    Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC. Learn More
  10. AZ 10417808

    Catalog No. A15294
    Quick View
    Caspase-3 inhibitor
    AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM). Learn More
  11. Ivachtin

    Catalog No. A15300
    Quick View
    Caspase-3 inhibitor
    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM). Learn More
  12. PETCM

    Catalog No. A15308
    Quick View
    Caspase-3 activator
    PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols. Learn More
  13. Ac-IEPD-AFC

    Catalog No. A15319
    Quick View
    Fluorogenic caspase substrate
    Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9. Learn More
  14. Ac-DEVD-CHO

    Catalog No. A15816
    Quick View
    Caspase Inhibitor
    Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor. Learn More
  15. Z-VEID-FMK

    Catalog No. A12611
    Quick View
    Caspase-6 inhibitor
    Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Learn More
  16. Z-VDVAD-FMK

    Catalog No. A12637
    Quick View
    Caspase-2 inhibitor
    Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. Learn More
  17. Z-DQMD-FMK

    Catalog No. A12697
    Quick View
    Caspase-3 inhibitor
    Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Learn More
  18. Z-IETD-FMK

    Catalog No. A12800
    Quick View
    caspase 8 inhibitor
    Z-IETD-FMK is a specific inhibitor of caspase 8. Learn More
  19. EP1013

    Catalog No. A11212
    Quick View
    caspase inhibitor
    EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes. Learn More
  20. BOC-D-FMK

    Catalog No. A11356
    Quick View
    caspase inhibitor
    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M. Learn More
  21. ML132

    Catalog No. A21557
    Quick View
    caspase 1 inhibitor
    ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM. Learn More
  22. PAC-1

    Catalog No. A11090
    Quick View
    Caspase activator
    PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM. Learn More
  23. Apoptosis Activator 2

    Catalog No. A11944
    Quick View
    Apoptosis Activator
    Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells Learn More
  24. LY573636 (Tasisulam)

    Catalog No. A13070
    Quick View
    Apoptosis inducer
    LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism. Learn More
  25. Z-FA-FMK

    Catalog No. A14284
    Quick View
    Irreversible Cysteine Protease inhibitor
    Z-FA-FMK is an irreversible cysteine protease inhibitor. Learn More
  26. 25-hydroxy Cholesterol

    Catalog No. A13704
    Quick View
    25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types Learn More
  27. Boc-D-FMK

    Catalog No. A15392
    Caspase inhibitor
    BOC-D-FMK is a Novel inhibitor of Caspase-3. Learn More
  28. Emricasan

    Catalog No. A11394
    Quick View
    Caspase inhibitor
    Emricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Learn More
  29. Z-YVAD-FMK

    Catalog No. A16317
    Quick View
    Caspase-1 inhibitor
    Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1. Learn More
  30. Z-VAD(OH)-FMK

    Catalog No. A16340
    Quick View
    Caspase inhibitor
    Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. Learn More
  31. Z-FA-FMK

    Catalog No. A16381
    Quick View
    Cysteine protease inhibitor
    Z-FA-FMK is an irreversible inhibitor of cysteine protease Learn More
    • New

    MX1013

    Catalog No. A17218
    Quick View
    pan-caspase inhibitor
    MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9. Learn More
  32. LY2886721

    Catalog No. A10543
    Quick View
    BACE1 inhibitor
    LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments. Learn More
  33. AZD3839

    Catalog No. A12825
    Quick View
    BACE1 inhibitor
    AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM. Learn More
  34. AMG-8718

    Catalog No. A14407
    Quick View
    BACE1 inhibitor
    AMG-8718 is a potent and orally efficacious BACE1 inhibitor. Learn More
  35. Timosaponin b-II

    Catalog No. A14591
    Quick View
    BACE1 Inhibitor
    Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage. Learn More
  36. gamma-secretase modulator 3

    Catalog No. A15090
    Quick View
    gamma-secretase modulator
    gamma-secretase modulator 3 is a gamma-secretase modulator. Learn More
  37. Compound W

    Catalog No. A15296
    Quick View
    Gamma-secretase modulator
    Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25. Learn More
  38. JLK 6

    Catalog No. A15301
    Quick View
    γ-secretase inhibitor
    JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways. Learn More
  39. MRK 560

    Catalog No. A15304
    Quick View
    γ-secretase inhibitor
    MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo. Learn More
  40. PF-03084014

    Catalog No. A11259
    Quick View
    γ-secretase inhibitor
    PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM . Learn More
  41. Flurbiprofen Axetil

    Catalog No. A13662
    Quick View
    gamma-secretase inhibitor
    Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID). Learn More
  42. L-685458

    Catalog No. A15899
    Quick View
    γ-secretase inhibitor
    L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. Learn More
  43. Begacestat (GSI-953)

    Catalog No. A11258
    Quick View
    γ-secretase inhibitor
    Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Learn More
  44. gamma-secretase modulator 1

    Catalog No. A11425
    Quick View
    Gamma-secretase modulator
    gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease. Learn More
  45. gamma-secretase modulator 2

    Catalog No. A11427
    Quick View
    Gamma-secretase modulator
    gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease. Learn More
  46. TC-E 5006

    Catalog No. A13217
    Quick View
    Gamma-secretase modulator
    TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Learn More
  47. Verubecestat (MK-8931)

    Catalog No. A16113
    Quick View
    β-secretase/BACE1 inhibitor
    Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Learn More
  48. CHF5074

    Catalog No. A16214
    Quick View
    γ-Secretase modulator
    CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively. Learn More
  49. Z-Ile-Leu-aldehyde

    Catalog No. A16215
    Quick View
    γ-Secretase inhibitor
    Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor. Learn More

Items 1 to 50 of 319 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction
Rewards