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VX-765 (Belnacasan)
Catalog No. A10984 Caspase-1/4 inhibitorVX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18. Learn More -
Z-VAD-FMK
Catalog No. A12373 Pan Caspase InhibitorZ-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo. Learn More -
Nivocasan (GS-9450)
Catalog No. A14100 Caspase inhibitorNivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. Learn More -
Z-DEVD-FMK
Catalog No. A13503 Caspase-3 InhibitorZ-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor. Learn More -
Z-LEHD-FMK
Catalog No. A14358 Caspase-9 InhibitorZ-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. Learn More -
Q-VD-OPh hydrate
Catalog No. A14915 Caspase inhibitorQ-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Learn More -
Z-WEHD-FMK
Catalog No. A14916 Caspase inhibitorZ-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. Learn More -
Caspase-3/7 Inhibitor I
Catalog No. A14919 Caspase-3/7 InhibitorCaspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM). Learn More -
Ac-LEHD-AFC
Catalog No. A15291 Fluorogenic caspase substrateAc-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC. Learn More -
AZ 10417808
Catalog No. A15294 Caspase-3 inhibitorAZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM). Learn More -
Ivachtin
Catalog No. A15300 Caspase-3 inhibitorIvachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM). Learn More -
PETCM
Catalog No. A15308 Caspase-3 activatorPETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols. Learn More -
Ac-IEPD-AFC
Catalog No. A15319 Fluorogenic caspase substrateAc-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9. Learn More -
Ac-DEVD-CHO
Catalog No. A15816 Caspase InhibitorAc-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor. Learn More -
Z-VEID-FMK
Catalog No. A12611 Caspase-6 inhibitorZ-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Learn More -
Z-VDVAD-FMK
Catalog No. A12637 Caspase-2 inhibitorZ-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. Learn More -
Z-DQMD-FMK
Catalog No. A12697 Caspase-3 inhibitorZ-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Learn More -
Z-IETD-FMK
Catalog No. A12800 caspase 8 inhibitorZ-IETD-FMK is a specific inhibitor of caspase 8. Learn More -
EP1013
Catalog No. A11212 caspase inhibitorEP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes. Learn More -
BOC-D-FMK
Catalog No. A11356 caspase inhibitorBoc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M. Learn More -
ML132
Catalog No. A21557 caspase 1 inhibitorML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM. Learn More -
PAC-1
Catalog No. A11090 Caspase activatorPAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM. Learn More -
Apoptosis Activator 2
Catalog No. A11944 Apoptosis ActivatorApoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells Learn More -
LY573636 (Tasisulam)
Catalog No. A13070 Apoptosis inducerLY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism. Learn More -
Z-FA-FMK
Catalog No. A14284 Irreversible Cysteine Protease inhibitorZ-FA-FMK is an irreversible cysteine protease inhibitor. Learn More -
25-hydroxy Cholesterol
Catalog No. A13704 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types Learn More -
Boc-D-FMK
Catalog No. A15392 -
Emricasan
Catalog No. A11394 Caspase inhibitorEmricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Learn More -
Z-YVAD-FMK
Catalog No. A16317 Caspase-1 inhibitorZ-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1. Learn More -
Z-VAD(OH)-FMK
Catalog No. A16340 Caspase inhibitorZ-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. Learn More -
Z-FA-FMK
Catalog No. A16381 Cysteine protease inhibitorZ-FA-FMK is an irreversible inhibitor of cysteine protease Learn More -
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New
MX1013
Catalog No. A17218 pan-caspase inhibitorMX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9. Learn More -
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LY2886721
Catalog No. A10543 BACE1 inhibitorLY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments. Learn More -
AZD3839
Catalog No. A12825 BACE1 inhibitorAZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM. Learn More -
AMG-8718
Catalog No. A14407 BACE1 inhibitorAMG-8718 is a potent and orally efficacious BACE1 inhibitor. Learn More -
Timosaponin b-II
Catalog No. A14591 BACE1 InhibitorTimosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage. Learn More -
gamma-secretase modulator 3
Catalog No. A15090 gamma-secretase modulatorgamma-secretase modulator 3 is a gamma-secretase modulator. Learn More -
Compound W
Catalog No. A15296 Gamma-secretase modulatorCompound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25. Learn More -
JLK 6
Catalog No. A15301 γ-secretase inhibitorJLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways. Learn More -
MRK 560
Catalog No. A15304 γ-secretase inhibitorMRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo. Learn More -
PF-03084014
Catalog No. A11259 γ-secretase inhibitorPF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM . Learn More -
Flurbiprofen Axetil
Catalog No. A13662 gamma-secretase inhibitorFlurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID). Learn More -
L-685458
Catalog No. A15899 γ-secretase inhibitorL-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. Learn More -
Begacestat (GSI-953)
Catalog No. A11258 γ-secretase inhibitorBegacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Learn More -
gamma-secretase modulator 1
Catalog No. A11425 Gamma-secretase modulatorgamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease. Learn More -
gamma-secretase modulator 2
Catalog No. A11427 Gamma-secretase modulatorgamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease. Learn More -
TC-E 5006
Catalog No. A13217 Gamma-secretase modulatorTC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Learn More -
Verubecestat (MK-8931)
Catalog No. A16113 β-secretase/BACE1 inhibitorVerubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Learn More -
CHF5074
Catalog No. A16214 γ-Secretase modulatorCHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively. Learn More -
Z-Ile-Leu-aldehyde
Catalog No. A16215 γ-Secretase inhibitorZ-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor. Learn More
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