Proteases

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  1. VX-765 (Belnacasan)

    Catalog No. A10984
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    Caspase-1/4 inhibitor
    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18. Learn More
  2. Z-VAD-FMK

    Catalog No. A12373
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    Pan Caspase Inhibitor
    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo. Learn More
  3. Nivocasan (GS-9450)

    Catalog No. A14100
    Caspase inhibitor
    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. Learn More
  4. Z-DEVD-FMK

    Catalog No. A13503
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    Caspase-3 Inhibitor
    Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor. Learn More
  5. Z-LEHD-FMK

    Catalog No. A14358
    Caspase-9 Inhibitor
    Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. Learn More
  6. Q-VD-OPh hydrate

    Catalog No. A14915
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    Caspase inhibitor
    Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Learn More
  7. Z-WEHD-FMK

    Catalog No. A14916
    Caspase inhibitor
    Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. Learn More
  8. Caspase-3/7 Inhibitor I

    Catalog No. A14919
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    Caspase-3/7 Inhibitor
    Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM). Learn More
  9. Ac-LEHD-AFC

    Catalog No. A15291
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    Fluorogenic caspase substrate
    Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC. Learn More
  10. AZ 10417808

    Catalog No. A15294
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    Caspase-3 inhibitor
    AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM). Learn More
  11. Ivachtin

    Catalog No. A15300
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    Caspase-3 inhibitor
    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM). Learn More
  12. PETCM

    Catalog No. A15308
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    Caspase-3 activator
    PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols. Learn More
  13. Ac-IEPD-AFC

    Catalog No. A15319
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    Fluorogenic caspase substrate
    Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9. Learn More
  14. Ac-DEVD-CHO

    Catalog No. A15816
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    Caspase Inhibitor
    Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor. Learn More
  15. Z-VEID-FMK

    Catalog No. A12611
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    Caspase-6 inhibitor
    Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Learn More
  16. Z-VDVAD-FMK

    Catalog No. A12637
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    Caspase-2 inhibitor
    Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. Learn More
  17. Z-DQMD-FMK

    Catalog No. A12697
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    Caspase-3 inhibitor
    Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Learn More
  18. Z-IETD-FMK

    Catalog No. A12800
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    caspase 8 inhibitor
    Z-IETD-FMK is a specific inhibitor of caspase 8. Learn More
  19. PAC-1

    Catalog No. A11090
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    Caspase activator
    PAC-1 is first procaspase activating compound. Learn More
  20. Apoptosis Activator 2

    Catalog No. A11944
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    Apoptosis Activator
    Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells Learn More
  21. LY573636 (Tasisulam)

    Catalog No. A13070
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    Apoptosis inducer
    LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism. Learn More
  22. Z-FA-FMK

    Catalog No. A14284
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    Irreversible Cysteine Protease inhibitor
    Z-FA-FMK is an irreversible cysteine protease inhibitor. Learn More
  23. 25-hydroxy Cholesterol

    Catalog No. A13704
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    25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types Learn More
  24. Boc-D-FMK

    Catalog No. A15392
    Caspase inhibitor
    BOC-D-FMK is a Novel inhibitor of Caspase-3. Learn More
  25. Z-YVAD-FMK

    Catalog No. A16317
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    Caspase-1 inhibitor
    Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1. Learn More
  26. Z-VAD(OH)-FMK

    Catalog No. A16340
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    Caspase inhibitor
    Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. Learn More
  27. Z-FA-FMK

    Catalog No. A16381
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    Cysteine protease inhibitor
    Z-FA-FMK is an irreversible inhibitor of cysteine protease Learn More
  28. gamma-secretase modulator 3

    Catalog No. A15090
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    gamma-secretase modulator
    gamma-secretase modulator 3 is a gamma-secretase modulator. Learn More
  29. Compound W

    Catalog No. A15296
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    Gamma-secretase modulator
    Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25. Learn More
  30. JLK 6

    Catalog No. A15301
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    γ-secretase inhibitor
    JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways. Learn More
  31. MRK 560

    Catalog No. A15304
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    γ-secretase inhibitor
    MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo. Learn More
  32. PF-03084014

    Catalog No. A11259
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    γ-secretase inhibitor
    PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM . Learn More
  33. Flurbiprofen Axetil

    Catalog No. A13662
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    gamma-secretase inhibitor
    Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID). Learn More
  34. L-685458

    Catalog No. A15899
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    γ-secretase inhibitor
    L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. Learn More
  35. Begacestat (GSI-953)

    Catalog No. A11258
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    γ-secretase inhibitor
    Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Learn More
  36. gamma-secretase modulator 1

    Catalog No. A11425
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    Gamma-secretase modulator
    gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease. Learn More
  37. gamma-secretase modulator 2

    Catalog No. A11427
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    Gamma-secretase modulator
    gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease. Learn More
  38. TC-E 5006

    Catalog No. A13217
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    Gamma-secretase modulator
    TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Learn More
  39. CHF5074

    Catalog No. A16214
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    γ-Secretase modulator
    CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively. Learn More
  40. Z-Ile-Leu-aldehyde

    Catalog No. A16215
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    γ-Secretase inhibitor
    Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor. Learn More
  41. RO4929097

    Catalog No. A10802
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    Gamma-secretase inhibitor
    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More
  42. BMS-708163 (Avagacestat)

    Catalog No. A10157
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    Gamma-secretase inhibitor
    BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis. Learn More
  43. MK-0752

    Catalog No. A11194
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    Gamma-secretase inhibitor
    MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. Learn More
  44. DAPT (GSI-IX)

    Catalog No. A10288
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    Gamma secretase inhibitor
    DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. Learn More
  45. YO-01027

    Catalog No. A11174
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    γ-secretase inhibitor
    YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent. Learn More
  46. LY-411575

    Catalog No. A11176
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    Gamma secretase inhibitor

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

    Learn More
  47. Semagacestat (LY450139)

    Catalog No. A10836
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    Gamma-secretase inhibitor
    Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM. Learn More
  48. LY2811376

    Catalog No. A11776
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    BACE1 inhibitor
    LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. Learn More
  49. BMS 433796

    Catalog No. A11337
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    γ-Secretase Inhibitor
    BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease. Learn More
  50. E 2012

    Catalog No. A11393
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    gamma-secretase modulator
    E 2012 is γ-secretase inhibitor. Learn More

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