AMG 548

Catalog No.: A10970
p38 MAPK inhibitor
AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
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Product Name Stock
AMG 548 5mg
AMG 548 10mg
AMG 548 50mg
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Biological Activity
Discription AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
Targets
Target Value
Product Information
Catalog Num A10970
Formula C29H27N5O
Molecular Weight 461.56
CAS Number 864249-60-5
SMILES O=C1N(C)C(NC[C@H](CC2=CC=CC=C2)N)=NC(C3=CC=NC=C3)=C1C4=CC=C5C(C=CC=C5)=C4
Synonyms AMG-548, AMG548
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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