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  1. Anti-inflammatory agent

    Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

  2. p38 MAPK inhibitor

    Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
  3. p38 MAPK inhibitor

    LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.
  4. p38 MAPK Inhibitor

    SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.
  5. p38 MAPK inhibitor

    SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
  6. p38 MAPK inhibitor

    Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
  7. p38 MAPK inhibitor

    AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
  8. p38 MAPK inhibitor

    VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM).
  9. p38 MAPK inhibitor

    VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .
  10. p38 MAPK inhibitor

    PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.
  11. p38 MAPK inhibitor

    SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM).
  12. p38 MAPK inhibitor

    PD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM.
  13. MK2 Inhibitor

    PF-3644022 is a potent and selective mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) inhibitor (Ki =3 nM).
  14. p38 MAPK inhibitor

    Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
  15. p38 MAPK inhibitor

    SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
  16. p38 MAPK inhibitor

    SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).
  17. p38 MAPK inhibitor

    TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.
  18. nAChR agonist

    Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.
  19. Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.
  20. p38 MAPK inhibitor

    ML-3043 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).
  21. p38 MAPK inhibitor

    Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.
  22. p38 MAPK inhibitor

    Talmapimod (SCIO-469) is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro).
  23. p38 MAPK inhibitor

    Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor.
  24. p38 MAPK inhibitor

    RWJ-67657 is a potent p38 MAPK inhibitor.
  25. p38 MAPK inhibitor

    Dilmapimod is p38 MAPK inhibitor.
  26. p38 MAPK inhibitor

    BMS-582949 Is a Dual Action p38 Kinase Inhibitor Well Suited To Avoid Resistance Mechanisms That Increase p38 Activation in Cells.
  27. p38 MAPK inhibitor

    TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.
  28. p38 MAPK inhibitor

    SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases.
  29. p38 MAPK inhibitor

    AL-8697 is a selective p38 MAPK(mitogen-activated protein Kinase) inhibitor, which is also named P38α inhibitor. It has the function of inhibiting the activity of P38 MAPK.
  30. P38 MAPK inhibitor

    SX 011 is a selective p38α, p38β and JNK-2 inhibitor. Reported to display no significant activity at p38γ, p38δ, ERK-2 and JNK-1.
  31. P38 MAPK inhibitor

    EO 1428 is a synthetic 4-aminobenzophenone small molecule identified in an optimization study for inhibitors of p38 MAP kinase.
  32. P38 MAPK inhibitor

    JX 401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).
  33. p38 MAPK Inhibitor

    CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM).
  34. p38 MAPK inhibitor

    SB 706504 is a p38 MAPK inhibitor, preventing LPS-induced transcription of a range of chemokineis and cytokines in chronic obstructive pulmonary disease monocyte derived macrophages.
  35. p38 MAPK inhibitor

    DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo.
  36. CK inhibitor

    TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively).
  37. oncometabolite

    Fumaric acid is a fundamental unit of nucleic acids.. It is a oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes.
  38. Antiparasitic

    Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookworm and other infestations.
  39. p38α MAPK inhibitor

    MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.
  40. p38α inhibitor

    p38α inhibitor 1 is a p38α inhibitor extracted from patent WO 2008076265 A1.
  41. p38-α MAPK inhibitor

    5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera.
  42. p38 MAPK inhibitor

    AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
  43. p38 MAPK inhibitor

    ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
  44. MAPK14 inhibitor

    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
  45. MAPK13 (p38 δ) inhibitor

    MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM.
  46. p38 MAPK inhibitor

    FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.
  47. p38α inhibitors

    R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.
  48. p38 MAP kinase inhibitor

    Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.385.42
  49. p38 MAPK inhibitor

    SB 203580 hydrochloride (RWJ 64809 hydrochloride) is a widely used p38 MAPK inhibitor.
  50. p38α MAPK inhibitor

    MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.

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