p38-MAPK

Cat. No.

A10824

CAS No.

152121-47-6

Adezmapimod (SB-203580)

Synonyms: SB-203580

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.

Cat. No.

A10823

CAS No.

152121-30-7

SB 202190

SB202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase.

Cat. No.

A10148

CAS No.

285983-48-4

Doramapimod (BIRB-796)

Synonyms: BIRB-796

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Cat. No.

A10092

CAS No.

464-92-6

Asiatic acid

Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

Cat. No.

A10982

CAS No.

745833-23-2

VX-702

VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM).

Cat. No.

A11078

CAS No.

586379-66-0

PH-797804

PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.

Cat. No.

A11221

CAS No.

152121-53-4

PD 169316

PD 169316 (PD169316) is a selective inhibitor of p38 MAPK.1 that inhibits p38 MAPK with an IC50 of 89 nM.

Cat. No.

A11321

CAS No.

1221485-83-1

Skepinone-L

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.

Cat. No.

A11582

CAS No.

303162-79-0

TAK-715

TAK 715 an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα), Wnt/beta-catenin signaling, and Inhibits 22 kinases by more than 80%, including CK 1δ/ε.

Cat. No.

A10545

CAS No.

862507-23-1

Ralimetinib dimesylate (LY2228820)

Synonyms: LY2228820

LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.

Cat. No.

A10895

CAS No.

945614-12-0

Pexmetinib (ARRY-614)

Synonyms: ARRY614

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.

Cat. No.

A10970

CAS No.

864249-60-5

AMG 548

AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.

Cat. No.

A10983

CAS No.

209410-46-8

Neflamapimod (VX-745)

Synonyms: VX745

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .

Cat. No.

A11101

CAS No.

116339-68-5

SKF 86002 Dihydrochloride

SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM).

Cat. No.

A11282

CAS No.

1276121-88-0

PF-3644022

PF-3644022 is a potent and selective mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) inhibitor (Ki =3 nM).

Cat. No.

A11562

CAS No.

193551-21-2

SB 239063

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.

Cat. No.

A11563

CAS No.

271576-80-8

SD-06

SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).

Cat. No.

A11618

CAS No.

375815-87-5

Varenicline Tartrate

Synonyms: CP 526555-18

Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.

Cat. No.

A12021

CAS No.

16830-15-2

Asiaticoside

Synonyms: Madecassol

Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.

Cat. No.

A12408

CAS No.

549505-65-9

ML-3043

ML-3043 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).

Cat. No.

A12526

CAS No.

585543-15-3

Losmapimod (GW856553X)

Synonyms: GW856553; GW856553X

Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.

Cat. No.

A12770

CAS No.

309913-83-5

Talmapimod (SCIO-469)

Synonyms: SCIO469

Talmapimod (SCIO-469) is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro).

Cat. No.

A13551

CAS No.

449811-01-2

Pamapimod (R-1503)

Synonyms: R 1503; Ro 4402257

Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor.

Cat. No.

A13552

CAS No.

215303-72-3

RWJ-67657

RWJ-67657 is a potent p38 MAPK inhibitor.

Cat. No.

A13553

CAS No.

444606-18-2

Dilmapimod

Synonyms: SB-681323; GW 681323

Dilmapimod is p38 MAPK inhibitor.