Amphotericin B

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Catalog No. A10073

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Amphotericin B 50mg A10073-50

Regular Price: $30.00

Special Price: $25.50

Amphotericin B 100mg A10073-100

Regular Price: $50.00

Special Price: $42.50

Amphotericin B 500mg A10073-500

Regular Price: $150.00

Special Price: $127.50

Amphotericin B 10mM * 1mL in DMSO A10073-10mM-D

Regular Price: $65.00

Special Price: $55.25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.

Amphotericin B

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Chemical Information

Catalog Num A10073
Actions N/A
M. Wt 924.1
Formula C47H73NO17
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1397-89-3
Synonyms Fungilin, Fungizone, AmBisome, Fungisome, Amphocil, Amphotec
SMILES code C[[email protected]]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[[email protected]]2[C@@H]([[email protected]](C[C@](O2)(C[[email protected]](C[[email protected]]([C@@H](CC[[email protected]](C[[email protected]](CC(=O)O[[email protected]]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[[email protected]]3[[email protected]]([[email protected]]([C@@H]([[email protected]](O3)C)O)N)O
Chemical Name 33-[(3-Amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

Biological Activity

Description
Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.
Targets
ergosterol

Solubility

Solubility (25°C)* In vitro DMSO 22 mg/mL (23.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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