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  1. Antifungal compound

    Amorolfine hydrochloride, is a morpholine antifungal reagent that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.
  2. Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.
  3. Aztreonam is a synthetic monocyclic beta-lactam antibiotic (a monobactam), with the nucleus based on a simpler monobactam isolated from Chromobacterium violaceum.
  4. Cefoselis is a widely used beta-lactam antibiotic.
  5. Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain, which does not allow the beta-lactamases to bind.
  6. Isoconazole nitrate (Travogen) is an azole antifungal reagent.
  7. Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic.
  8. Protein synthesis inhibitor

    Linezolid is a synthetic antibiotic used for the treatment of serious infections.
  9. Polymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.
  10. Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation.
  11. Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.
  12. Neuraminidase Inhibitor

    Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells.
  13. protein synthesis inhibitor

    Retapamulin is an antibacterial agent, specifically a protein synthesis inhibitor
  14. PA-824 is an experimental anti-tuberculosis drug.
  15. HSV DNA replication inhibitor

    Fiacitabine is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively.
  16. Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.
  17. Oseltamivir is an antiviral drug, which may slow the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.
  18. Butenafine Hydrochloride is an antifungal which is used to control dermal fungal infections such as athletes foot and ring worm.
  19. Cefradine is a first generation cephalosporin antibiotic.
  20. Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).
  21. Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic.
  22. BM212 is inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.
  23. TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.
  24. Moxidectin is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms.
  25. SQ109 is an orally active, small molecule antibiotic for treatment of pulmonary T(tuberculosis).
  26. Fusidate Sodium is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.
  27. Neuraminidase inhibitor

    Laninamivir is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.
  28. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.
  29. Eperezolid is an oxazolidinone antibiotic. It demonstrated good in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml).
  30. Ganciclovir Mono-O-acetate is a ganciclovir derivative.
  31. DL-cycloserine is an antibacterial (tuberculostatic).
  32. Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, Streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone.
  33. Cefixime is a third generation cephalosporin antibiotic that is orally active.
  34. Rolitetracycline is a tetracycline antibiotic.
  35. Solithromycin is a novel ketolide antibiotic. Solithromycin (CAS 760981-83-7) can be used for anti-infection, and It is expected to be the first macrolide antibiotic available in intravenous, oral, and pediatric suspension formulations in over 20 years.
  36. Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome.
  37. Mefloquine HCl is a blood schizonticide by inhibiting hemozoin formation.
  38. 1,3-beta-D-glucan synthesis inhibitor

    Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis.
  39. Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by bacteria
  40. Betamipron is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.
  41. Imipenem is an intravenous betalactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in 1980.
  42. Torezolid is an oxazolidinone drug in phase-II clinical trials for complicated skin and skin-structure infections (cSSSI), including those caused by Methicillin-resistant Staphylococcus aureus (MRSA).
  43. Amadacycline is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome.
  44. Amadacycline methanesulfonate is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome.
  45. AN-2690, an antifungal agent with activity against Trichophyton species, in a topical solution formulation, for the potential treatment of onychomycosis.
  46. I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.
  47. anti-tuberculosis

    TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.
  48. Bronopol is antibacterial agent, used as preservative in cosmetic industry.
  49. Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.

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