AS1842856

Catalog No.: A15871
Foxo1 Inhibitor
AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.
Grouped product items
Size Price Stock Qty
5mg
$40.00
In stock
10mg
$60.00
In stock
25mg
$100.00
In stock
50mg
$150.00
In stock
100mg
$230.00
In stock
200mg
$345.00
In stock
500mg
$590.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Adooq's AS1842856 has been cited by 4 publications
  • Jungang Lan, .et al. , PLoS Pathog, 2023, Aug 18;19(8) PMID: 37594999
  • Jiunn-Chang Lin, .et al. , Am J Cancer Res, 2023, Sep 15;13(9):4125-4144 PMID: 37818050
  • Yuta Tanizaki, .et al. , Commun Biol, 2022, 5: 112 PMID: 35132135
  • Zhongsheng Zhu, .et al. , BMC Complement Altern Med, 2019, 19: 111 PMID: 31146723
Biological Activity
DescriptionAS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.
Targets
TargetValue
Product Information
Catalog NumA15871
FormulaC18H22FN3O3
Molecular Weight347.38
CAS Number836620-48-5
SMILESO=C1C(C(O)=O)=CN(CC)C2=C1C(N)=C(F)C(NC3CCCCC3)=C2
SynonymsAS 1842856, AS-1842856
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO23 mg/mL (66.2 mM)
WaterInsoluble
EthanolInsoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM28.79 mL143.93 mL287.87 mL
0.5 mM5.76 mL28.79 mL57.57 mL
1 mM2.88 mL14.39 mL28.79 mL
5 mM0.58 mL2.88 mL5.76 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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