Catalog No.
Product Name
Application
Product Information
Citations
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Foxo1 Inhibitor
AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.- Jungang Lan, .et al. , PLoS Pathog, 2023, Aug 18;19(8) PMID: 37594999
- Jiunn-Chang Lin, .et al. , Am J Cancer Res, 2023, Sep 15;13(9):4125-4144 PMID: 37818050
- Yuta Tanizaki, .et al. , Commun Biol, 2022, 5: 112 PMID: 35132135
- Zhongsheng Zhu, .et al. , BMC Complement Altern Med, 2019, 19: 111 PMID: 31146723
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Foxo1 Inhibitor
AS1708727 is an orally active inhibitor of Foxo1, exhibiting EC50 values of 0.33 μM for glucose-6-phosphatase (G6Pase) and 0.59 μM for phosphoenolpyruvate carboxykinase (PEPCK). This compound plays a significant role in modulating metabolic pathways and is valuable for research into glucose homeostasis and metabolic disorders. AS1708727 can be utilized in studies investigating the therapeutic potential of targeting Foxo1 in various diseases, including diabetes and cancer.
