AT7867

AKT inhibitor

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Catalog No. A10094

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT7867 10mg A10094-10

Regular Price: $150.00

Special Price: $120.00

AT7867 25mg A10094-25

Regular Price: $350.00

Special Price: $280.00

AT7867 50mg A10094-50

Regular Price: $600.00

Special Price: $480.00

AT7867 100mg A10094-100

Regular Price: $950.00

Special Price: $760.00

AT7867 10mM * 1mL in DMSO A10094-10mM-D

Regular Price: $147.00

Special Price: $117.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.

AT7867

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Chemical Information

Catalog Num A10094
Actions Inhibitor
M. Wt 337.9
Formula C20H20ClN3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 857531-00-1
Synonyms AT-7867
SMILES code C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl
Chemical Name 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine

Biological Activity

Description
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
Targets
Target Value
Akt2IC50: 17nM
PKAIC50: 20nM
Akt1IC50: 32nM
Akt3IC50: 47nM
p70S6KIC50: 85nM
RSK1IC50: >100nM
CDK2IC50: >1μM
GSK-3βIC50: >1μM
c-SrcIC50: >1μM
Chk1IC50: >1μM
EGFRIC50: >1μM
FGFR3IC50: >1μM
MEK1IC50: >1μM
PDK-1IC50: >1μM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
Tie-2IC50: >1μM

Solubility

Solubility (25°C) * In vitro DMSO 68 mg/mL (201.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (14.79 mM)
In vivo 15% Captisol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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