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Akt

Items 1-50 of 58

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. A10003
    MK-2206 2HCl

    AKT Inhibitor

    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
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  2. A10094
    AT7867

    AKT inhibitor

    AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
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  3. A10453
    Honokiol

    Antiangiogenic and Antitumor Agent

    Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines.
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  4. A10693
    Palomid 529 (P529)

    AKT Inhibitor

    Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation.
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  5. A10709
    Perifosine (NSC-639966)

    Akt inhibitor

    Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
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  6. A11024
    PF-04691502

    PI3K/mTOR Inhibitor

    PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway.
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  7. A11030
    GSK690693

    AKT inhibitor

    GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
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  8. A11031
    CCT128930

    AKT Inhibitor

    CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference.
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  9. A11032
    PHT-427

    AKT Inhibitor

    PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
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  10. A11033
    Triciribine phosphate (NSC-280594)

    AKT Inhibitor

    Triciribine phosphate inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation.
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  11. A11034
    A-674563

    Akt inhibitor

    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
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  12. A11246
    GDC-0068 (Ipatasertib, RG-7440)

    Akt Inhibitor

    GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays
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  13. A11262
    Cenisertib

    multi-kinase inhibitor

    Cenisertib (AS-703569) is a multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3.
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  14. A11285
    AKT Kinase Inhibitor

    Akt kinase inhibitor

    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.
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  15. A11286
    AKT inhibitor VIII (AKTI-1/2)

    AKT inhibitor

    AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).
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  16. A11287
    A-443654

    Akt inhibitor

    A-443654, a specific Akt inhibitor with Ki value of 160 pM, interferes with mitotic progression and bipolar spindle formation.
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  17. A11453
    Isobavachalcone

    Akt inhibitor

    Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM).
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  18. A11759
    AZD5363

    AKT inhibitor

    AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.
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  19. A12081
    SC 66

    Akt inhibitor

    SC 66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. It exhibits anticancer activity in vitro and in vivo.
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  20. A12435
    Akt-l-1

    AKT1 inhibitor

    Akt-I-1 is a specific inhibitor of Akt1 (IC(50) 4.6 μM) and does not inhibit AKT2, or AKT3
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  21. A12464
    AT13148

    multi-AGC kinase inhibitor

    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
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  22. A12720
    TIC10 isomer

    AKT inhibitor?€?

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics.
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  23. A12877
    KP372-1

    Akt Inhibitor

    KP372-1 is a synthetic small molecule AKT inhibitor.
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  24. A13030
    Afuresertib HCl

    AKT inhibitor?€?

    Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
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  25. A13210
    Triciribine

    AKT Inhibitor

    Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt.
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  26. A13364
    Borussertib

    Akt inhibitor

    Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt.
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  27. A13460
    Deguelin

    Deguelin is a natural product that displays profound antiproliferative activity.
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  28. A13554
    SR-13668

    AKT inhibitor?€?

    SR-13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities.
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  29. A13590
    10-DEBC HCl

    AKT/PKB inhibitor?€?

    10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein.
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  30. A14121
    CTX 0294885

    Broad-Spectrum Kinase Inhibitor

    CTX-0294885 is a novel broad-spectrum kinase inhibitor. CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro.
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  31. A14138
    Miltefosine

    PI3K/Akt inhibitor

    Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa
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  32. A15006
    AT7867 2HCl

    Akt inhibitor

    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family.
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  33. A15541
    SC79

    Akt phosphorylation activator

    SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation.
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  34. A15809
    GSK2141795 (Uprosertib, GSK795)

    Akt inhibitor

    Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.
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  35. A15903
    TIC10

    Akt Inhibitor?€?

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.
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  36. A16233
    Tomatidine

    ERK/Akt/NF-kB inhibitor

    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties.
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  37. A16285
    Akt1 and Akt2-IN-1

    AKT 1/2 inhibitor

    Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.
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  38. A16286
    ARQ-092 (Miransertib)

    AKT inhibitor

    ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).
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  39. A16392
    Afuresertib

    Akt inhibitor

    Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
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  40. A17293
    4-Methylbenzylidene camphor

    4-Methylbenzylidene camphor(4-MBC; Enzacamene)is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.
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  41. A19825
    Guggulsterone

    Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt.
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  42. A20147
    AKT-IN-2

    AKT inhibitor

    AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1.
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  43. A20255
    Recilisib (free acid)

    radioprotectant

    Recilisib is a radioprotectant, which can activate AKT, PI3K activities in cells.
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  44. A20421
    BAY1125976

    allosteric Akt1/Akt2 inhibitor

    BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
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  45. A20847
    AS194949

    SHIP-2 inhibitor

    AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5?? phosphatase 2) inhibitor, with an IC50 of 620 nM. AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes.
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  46. A20924
    3CAI

    AKT1/AKT2 inhibitor

    3CAI is a potent and specific AKT1 and AKT2 inhibitor.
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  47. A21009
    AKT-IN-1

    AKT inhibitor

    AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM.
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  48. A21053
    GSK2110183 analog 1

    GSK2110183 analog 1 is the structural analogue of GSK2110183.
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  49. A21087
    Solenopsin

    ATP-competitive AKT inhibitor

    Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM .
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  50. A21198
    YS-49

    PI3K/Akt activator

    YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells.
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Items 1-50 of 58

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