BIX02188

MKK/MEK inhibitor

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Catalog No. A10150

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BIX02188 5mg A10150-5
$90.00
BIX02188 10mg A10150-10
$160.00
BIX02188 50mg A10150-50
$450.00
BIX02188 100mg A10150-100
$750.00
BIX02188 10mM * 1mL in DMSO A10150-10mM-D
$136.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BIX02188 is a potent and selective inhibitor of MEK5.

BIX02188

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Chemical Information

Catalog Num A10150
Actions Inhibitor
M. Wt 426.5
Formula C26H26N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1094614-84-2
Synonyms BIX-02188
SMILES code CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4
Chemical Name (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

Biological Activity

Description
BIX02188 is a potent and selective inhibitor of MEK5.
Targets
Target Value
MEK5IC50: 4.3nM
ERK5IC50: 810nM
TGFβR1IC50: 1.8μM
MEK1IC50: >6.3μM
MEK2IC50: >6.3μM
ERK1IC50: >6.3μM
JNK2IC50: >6.3μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM

Solubility

Solubility (25°C) * In vitro DMSO 43 mg/mL (104.24 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (7.27 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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