CAL-101 (GS-1101)

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PI3K inhibitor

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Catalog No. A10172

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CAL-101 10mg A10172-10
$40.00
CAL-101 25mg A10172-25
$90.00
CAL-101 50mg A10172-50
$160.00
CAL-101 100mg A10172-100
$300.00
CAL-101 (GS-1101) 10mM * 1mL in DMSO A10172-10mM-D
$76.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.

CAL-101 (GS-1101)

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Chemical Information

Catalog Num A10172
Actions Inhibitor
M. Wt 415.4
Formula C22H18FN7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 870281-82-6
Synonyms CAL101
SMILES code CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
Chemical Name (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

Biological Activity

Description
CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.
Targets
Target Value
p110δIC50: 2.5nM
p110γIC50: 89nM
p110βIC50: 565nM
p110αIC50: 820nM
hVps34IC50: 978nM
C2βIC50: >1μM
mTORIC50: >1μM
PIP5KαIC50: >1μM
PIP5KβIC50: >1μM
DNA-PKIC50: 6.729μM

Solubility

Solubility (25°C) * In vitro DMSO 83 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 35 mg/mL (84.25 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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