Target & Activity
| Target | Activity | Value |
|---|---|---|
| PI3Kα | IC50 | 14nM |
| PI3Kγ | IC50 | 36nM |
| PI3Kβ | IC50 | 0.12μM |
| PI3Kδ | IC50 | 0.50μM |
| mTOR | IC50 | 1.6μM |
| C2β | IC50 | 5.3μM |
| C2α | IC50 | >10μM |
| Vps34 | IC50 | >10μM |
8 targets · Scroll to view more
Fig. 1 · Structure
Documents & Downloads
CH5132799
Cat. No.
A11169
CAS
1007207-67-1
PI3K inhibitor
CH5132799 is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kα (IC(50)=0.014 μM).
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1007207-67-1 |
| Applications | PI3K inhibitor |
| Formula | C15H19N7O3S |
| Molecular Weight | 377.42 |
| SMILES | CS(=O)(=O)N1CCC2=C(N=C(N=C21)N3CCOCC3)C4=CN=C(N=C4)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 12 mg/mL (31.79 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 28 mg/mL
- Vehicle
- 1% DMSO+30% polyethylene glycol+1% Tween 80
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.