Compound 401

DNA-PK inhibitor

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Catalog No. A11778

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Compound 401 10mg A11778-10
$125.00
Compound 401 25mg A11778-25
$300.00
Compound 401 50mg A11778-50
$550.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 ?M).

Compound 401

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Chemical Information

Catalog Num A11778
Actions Inhibitor
M. Wt 281.31
Formula C16H15N3O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 168425-64-7
Synonyms N/A
SMILES code C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2
Chemical Name 2-(4-Morpholinyl)-4H-pyrimido[2,1-a?]isoquinolin-4-one

Biological Activity

Description
Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 ?M).

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