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Cryptotanshinone

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Stat3 inhibitor

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Catalog No. A10244

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Cryptotanshinone 10mg A10244-10

Regular Price: $40.00

Special Price: $32.00

Cryptotanshinone 25mg A10244-25

Regular Price: $90.00

Special Price: $72.00

Cryptotanshinone 50mg A10244-50

Regular Price: $170.00

Special Price: $136.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR.

Cryptotanshinone

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Chemical Information

Catalog Num A10244
Actions Inhibitor
M. Wt 296.4
Formula C19H20O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 35825-57-1
Synonyms Tanshinone
SMILES code C[[email protected]]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
Chemical Name (r)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione

Biological Activity

Description
Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR.
Targets
STAT3 (HCT-116 cells)
4.6 μM

Solubility

Solubility (25°C)* In vitro DMSO 5 mg/mL heating (16.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL heating (3.37 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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