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DNA/RNA Synthesis inhibitor

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Catalog No. A11065

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CX-5461 5mg A11065-5

Regular Price: $90.00

Special Price: $81.00

CX-5461 10mg A11065-10

Regular Price: $160.00

Special Price: $144.00

CX-5461 50mg A11065-50

Regular Price: $450.00

Special Price: $405.00

CX-5461 100mg A11065-100

Regular Price: $750.00

Special Price: $675.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.


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Chemical Information

Catalog Num A11065
Actions Inhibitor
M. Wt 513.6
Formula C27H27N7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1138549-36-6
Synonyms CX5461
Chemical Name 2-(4-methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide

Biological Activity

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.
A375 MIA PaCa-2 Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells) HCT-116
58 nM(ED50)74 nM(ED50)142 nM167 nM(ED50)


Solubility (25°C)* In vitro DMSO 0.02 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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