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|Storage||at -20°C 3 years Powder|
|SMILES code||CCC[[email protected]@H](C1=CN=CC=C1)NC2=NC(=NC=C2C)C3=CC(=C(C=C3)NC(=O)NCC)OC|
|CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ± 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing.|
|Solubility (25°C)*||In vitro||DMSO||86 mg/mL (197.91 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||20 mg/mL (46.02 mM)|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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