Catalog No.
Product Name
Application
Product Information
Product Citation
- Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
- Sochaj-Gregorczyk AM, .et al. , J Immunother, 2016, Jul-Aug;39(6):223-32 PMID: 27227324
-
Microtubule Associated inhibitor
Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.- Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
- Yu Pan, .et al. , Nucleic Acids Res, 2021, Jan 11;49(1):38-52 PMID: 33290562
- Li-Li Li, .et al. , Nat Commun, 2020, Oct 9;11(1):5107 PMID: 33037199
- Baglo Y, .et al. , Photochem Photobiol, 2019, Dec 19 PMID: 31856423
- Owiti AO, .et al. , AAPS PharmSciTech, 2018, Nov;19(8):3534-3549 PMID: 30151731
- Owiti AO, .et al. , AAPS PharmSciTech, 2018, Oct;19(7):3110-3122 PMID: 30112614
-
microtubule assembly inhibitor
4-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly. -
Microtubule Associated inhibitor
ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. - Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
- Chloroxine is an antibacterial drug useful for dandruff and seborrheic dermatitis.
- Colchicine is an inhibitor of microtubules by specific binding to tubulin.
- Yao-Yu Hsieh, .et al. , Mol Oncol, 2023, Oct 16 PMID: 37842807
-
Microtubule Inhibitor
CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ?? 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing. -
Microtubule Associated inhibitor
Docetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions.- Adi Jacob Berger, .et al. , Nat Cancer, 2021, 2, 1055-1070 PMID: 35121883
-
Microtubule Associated inhibitor
Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. -
Microtubule Associated inhibitor
Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.- Yicheng Zhu, .et al. , Neurosci Res, 2021, Apr 17 PMID: 33864880
- Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin.
-
Tubulin inhibitor
Vincristine is a mitotic inhibitor, and is used in cancer chemotherapy. -
Microtubule Associated inhibitor
Vinflunine Tartrate is a tartrate salt of vinflunine that destabilizes microtubules with an IC50 of 18.8 nM and interferes with the dynamics of microtubules during cell division. - Vinorelbine is the first 5??NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus.
- Rotem Ben-Hamo, .et al. , Nat Commun, 2020, 11: 3296
- Roma Kaul, .et al. , Br J Cancer, 2019, 121, pages611-621 PMID: 31481735
- Nicholas F. Dybdal-Hargreaves, .et al. , Oncotarget, 2018, Jan 19; 9(5): 5545-5561 PMID: 29464017
- APRIL L. RISINGER, .et al. , Anticancer Res, 2015, Nov; 35(11): 5845-5850 PMID: 26504006
- Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
- Baihong Guo, .et al. , Neurobiol Aging, 2020, Sep 12;96:223-232 PMID: 33039900
-
microtubule inhibitor
Ixabepilone is an epothilone B analog- Dong-Sheng Cao, .et al. , Eur J Med Chem, 2020, Aug 1;199:112421 PMID: 32428794
- Hoque M, .et al. , Pharmacol Res, 2018, Aug;134:166-178 PMID: 29944980
- APRIL L. RISINGER, .et al. , Anticancer Res, 2015, Nov; 35(11): 5845-5850 PMID: 26504006
- Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.
- Li-Li Li, .et al. , Nat Commun, 2020, Oct 9;11(1):5107 PMID: 33037199
-
Microtubule Associated inhibitor
Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment- Satoshi Endo, .et al. , J Biochem, 2021, Mar 17 PMID: 33729485
- Tomohiro Nabekura, .et al. , Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509
- Cevipabulin (TTI-237), an antimicrotubule agent, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules.
- Yao-Yu Hsieh, .et al. , Mol Oncol, 2023, Oct 16 PMID: 37842807
- Combretastatin A4 is an antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.
- Eribulin mesylate is the mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity.
- Tomohiro Nabekura, .et al. , Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509
- Snyder C, .et al. , Toxicol In Vitro, 2018, Aug;50:109-123 PMID: 29427706
-
microtubule-targeting agent
Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. -
microtubule inhibitor
Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.- Chiao-Ping Chen, .et al. , Biomed Pharmacother, 2023, Oct:166:115389 PMID: 37659202
-
microtubule depolymerizing agent
Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. -
microtubule dynamics inhibitor
Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. - Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.
- Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
-
microtubule stabilizer
Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity.- Payal Ranaa, .et al. , Toxicol In Vitro, 2017, Dec;45(Pt 1):111-118 PMID: 28843493
-
Microtubule polymerization inhibitor
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor - 7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
- 7-xylosyltaxol is a taxol derivative, Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.
- Docetaxel trihydrate, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
- Ogawa C, .et al. , Yakugaku Zasshi, 2018, 138(7):973-984 PMID: 29962477
-
tau protein aggregation inhibitor
TRx 0237 (LMT) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. -
tubulin polymerization inhibitor
Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. - Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
-
microtubule destabilizing agents
Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system.
