Dasatinib (BMS-354825)

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Abl-Src inhibitor

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Catalog No. A10290

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Dasatinib (BMS-354825) 25mg A10290-25

Regular Price: $60.00

Special Price: $51.00

Dasatinib (BMS-354825) 50mg A10290-50

Regular Price: $90.00

Special Price: $76.50

Dasatinib (BMS-354825) 100mg A10290-100

Regular Price: $140.00

Special Price: $119.00

Dasatinib (BMS-354825) 200mg A10290-200

Regular Price: $220.00

Special Price: $187.00

Dasatinib (BMS-354825) 10mM * 1mL in DMSO A10290-10mM-D

Regular Price: $71.00

Special Price: $60.35

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.

Dasatinib (BMS-354825)

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Chemical Information

Catalog Num A10290
Actions Inhibitor
M. Wt 488.0
Formula C22H26ClN7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 302962-49-8
Synonyms Sprycel
SMILES code CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
Chemical Name N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide monohydrate

Biological Activity

Description
Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.
Targets
Abl (Cell-free assay) Src (Cell-free assay) c-Kit (D816V) (Cell-free assay) c-Kit (wt) (Cell-free assay)
0.6 nM0.8 nM37 nM79 nM

Solubility

Solubility (25°C) * In vitro DMSO 98 mg/mL (200.81 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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