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Biological Activity
Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of <1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.
| In vitro | DMSO | 85 mg/mL (162.06 mM) | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.07 mL | 95.33 mL | 190.67 mL |
| 0.5 mM | 3.81 mL | 19.07 mL | 38.13 mL |
| 1 mM | 1.91 mL | 9.53 mL | 19.07 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.81 mL |
*The above data is based on the productmolecular weight 524.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15060 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 854001-07-3 |
| Formula | C22H27Cl2N7O2S |
| M. Wt | 524.47 |
| Purity | >98% |
| Synonyms | BMS-354825 hydrochloride, Sprycel hydrochloride, BMS354825 hydrochloride, BMS 354825 hydrochloride |
| SMILES | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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