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Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of <1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.07 mL | 95.33 mL | 190.67 mL |
| 0.5 mM | 3.81 mL | 19.07 mL | 38.13 mL |
| 1 mM | 1.91 mL | 9.53 mL | 19.07 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.81 mL |
*The above data is based on the productmolecular weight 524.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A15060 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 524.47 |
| Formula | C22H27Cl2N7O2S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 854001-07-3 |
| Synonyms | BMS-354825 hydrochloride, Sprycel hydrochloride, BMS354825 hydrochloride, BMS 354825 hydrochloride |
| SMILES | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C.Cl |
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