Dasatinib Monohydrate

Catalog No.: A16320

Dasatinib Monohydrate

Dasatinib Monohydrate Chemical Structure

CAS NO. 863127-77-9

Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.

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500 mg
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1000 mg
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  • Izumi-Nakaseko H, .et al. Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors, Cardiovasc Toxicol, 2019, Jul 6 PMID: 31280457

Biological Activity

Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.76 mL 98.81 mL 197.62 mL
0.5 mM 3.95 mL 19.76 mL 39.52 mL
1 mM 1.98 mL 9.88 mL 19.76 mL
5 mM 0.4 mL 1.98 mL 3.95 mL

*The above data is based on the productmolecular weight 506.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16320
CAS No. 863127-77-9
Formula C22H28ClN7O3S
M. Wt 506.02
Purity >98%
Synonyms BMS354825
SMILES CC1=C(/N=C(O)/C(S2)=CN=C2NC3=CC(N4CCN(CCO)CC4)=NC(C)=N3)C(Cl)=CC=C1.O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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