ENMD-2076

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Aurora Inhibitor

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Catalog No. A10352

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ENMD-2076 5mg A10352-5

Regular Price: $80.00

Special Price: $68.00

ENMD-2076 10mg A10352-10

Regular Price: $140.00

Special Price: $119.00

ENMD-2076 50mg A10352-50

Regular Price: $400.00

Special Price: $340.00

ENMD-2076 100mg A10352-100

Regular Price: $650.00

Special Price: $552.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ENMD-2076 is a novel, orally-active antimitotic and antiangiogenic molecule inhibits Aurora A as well as tyrosine kinases that drive tumor vascularization, including VEGFR2 (KDR), PDGFR and the FGF receptors.

ENMD-2076

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Chemical Information

Catalog Num A10352
Actions Inhibitor
M. Wt 375.5
Formula C21H25N7
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 934353-76-1, 1291074-87-7
Synonyms ENMD2076, ENMD 2076
SMILES code CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)/C=C/C4=CC=CC=C4
Chemical Name (E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine

Biological Activity

Description
ENMD-2076 is a novel, orally-active antimitotic and antiangiogenic molecule inhibits Aurora A as well as tyrosine kinases that drive tumor vascularization, including VEGFR2 (KDR), PDGFR and the FGF receptors.
Targets
Target Value
FLT3IC50: 1.86nM
RETIC50: 10.4nM
AuroraAIC50: 14nM
VEGFR3/FLT4IC50: 15.9nM
SrcIC50: 20.2nM
NTRK1/TRKAIC50: 24.2nM
CSF-1R/c-FmsIC50: 24.8nM
LCKIC50: 43.7nM
FAKIC50: 54.9nM
PDGFRαIC50: 56.4nM
VEGFR2/KDRIC50: 58.2nM
BLKIC50: 69.4nM
FGFR2IC50: 70.8nM
YES1IC50: 78.4nM
Abl1(T315I)IC50: 81.3nM
FGFR1IC50: 92.7nM
FynIC50: 112nM
JAK2IC50: 120nM
KitIC50: 120nM
AuroraBIC50: 350nM

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