EW-7197

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ALK4/ALK5 inhibitor

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Catalog No. A14213

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
EW-7197 5mg A14213-5

Regular Price: $130.00

Special Price: $104.00

EW-7197 10mg A14213-10

Regular Price: $220.00

Special Price: $176.00

EW-7197 25mg A14213-25

Regular Price: $440.00

Special Price: $352.00

EW-7197 10mM * 1mL in DMSO A14213-10mM-D

Regular Price: $114.00

Special Price: $91.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

EW-7197 is a highly potent, selective, and orally bioavailable TGF-?? I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively

EW-7197

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Chemical Information

Catalog Num A14213
Actions Inhibitor
M. Wt 399.42
Formula C22H18FN7
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1352608-82-2
Synonyms EW7197
SMILES code CC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4
Chemical Name N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine

Biological Activity

Description
EW-7197 is a highly potent, selective, and orally bioavailable TGF-?? I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
Targets
Target Value
ALK5IC50: 11nM
ALK4IC50: 13nM
ALK1IC50: >10μM
ALK2IC50: >10μM
ALK3IC50: >10μM
ALK6IC50: >10μM

Solubility

Solubility (25°C)* In vitro DMSO 79 mg/mL (197.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol 43 mg/mL heating (107.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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