TGF-β/Smad Inhibitors

Cat. No.

A12358

CAS No.

909910-43-6

A 83-01

A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7

Cat. No.

A10826

CAS No.

301836-41-9

SB 431542

SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I ALK receptors ALK4, ALK5, and ALK7 .

Cat. No.

A11133

CAS No.

700874-71-1

LY2109761

LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

Cat. No.

A11017

CAS No.

700874-72-2

Galunisertib (LY2157299)

Synonyms: LY-2157299

LY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor.

Cat. No.

A11205

CAS No.

1062368-24-4

LDN193189

LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.

Cat. No.

A11762

CAS No.

446859-33-2

RepSox (SJN 2511)

Synonyms: E-616452; SJN 2511; ALK 5 inhibitor

RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).

Cat. No.

A11478

CAS No.

1062368-62-0

LDN193189 HCl

Synonyms: LDN 193189

LDN193189 HCl is the hydrochloride salt of LDN193189. LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.

Cat. No.

A14213

CAS No.

1352608-82-2

Vactosertib (EW-7197)

Synonyms: EW7197

EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively

Cat. No.

A16065

CAS No.

521984-48-5

SIS3

SIS3 is a novel specific inhibitor of Smad3. It has effect on transforming growth factor-beta1-induced extracellular matrix expression.

Cat. No.

A16209

CAS No.

53179-13-8

Pirfenidone

Synonyms: AMR69

Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.

Cat. No.

A11083

CAS No.

452342-67-5

GW788388

GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).

Cat. No.

A12820

CAS No.

1206711-16-1

DMH-1

DMH-1 is a selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM).

Cat. No.

A12924

CAS No.

1099644-42-4

ITD-1

ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells.

Cat. No.

A10449

CAS No.

520-33-2

Hesperetin

Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, –Chen Pi.– Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.

Cat. No.

A10827

CAS No.

356559-20-1

SB 525334

SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells

Cat. No.

A11157

CAS No.

694433-59-5

SB-505124

SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively).

Cat. No.

A12821

CAS No.

1432597-26-6

LDN-212854

LDN-212854 is an ALK2-Biased BMP Type I Receptor Kinase Inhibitor.

Cat. No.

A12926

CAS No.

4727-31-5

Kartogenin

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes

Cat. No.

A13446

CAS No.

396129-53-6

LY364947

Synonyms: HTS 466284 ,TGF-β RI Kinase Inhibitor

LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase).

Cat. No.

A14066

CAS No.

627536-09-8

SD-208

SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM); displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively.

Cat. No.

A14162

CAS No.

476474-11-0

F9995-0144

N/A

Cat. No.

A14298

CAS No.

1062368-49-3

ML347

Synonyms: ML 347,ML-347

ML347 is a selective BMP receptor inhibitor .

Cat. No.

A14311

CAS No.

1431985-92-0

K02288

K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6.

Cat. No.

A14436

CAS No.

607737-87-1

A 77-01

A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.

Cat. No.

A14810

CAS No.

546-43-0

Alantolactone

Alantolactone, an allergenic sesquiterpene lactone, has recently been found to have significant antitumor effects on malignant tumor cells.