FTI-277 HCl

FTase Inhibitor

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Catalog No. A14439

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
FTI-277 HCl 5mg A14439-5
$90.00
FTI-277 HCl 10mg A14439-10
$150.00
FTI-277 HCl 25mg A14439-25
$300.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.

FTI-277 HCl

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Chemical Information

Catalog Num A14439
Actions Inhibitor
M. Wt 484.07
Formula C22H30ClN3O3S2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 180977-34-8
Synonyms FTI 277, FTI277
SMILES code COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.Cl.Cl
Chemical Name (Z)-5-(((R)-2-amino-3-mercaptopropyl)amino)-N-((S)-1-methoxy-4-(methylthio)-1-oxobutan-2-yl)-[1,1'-biphenyl]-2-carbimidic acid hydrochloride

Biological Activity

Description
FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
Targets
FTase GGTase I
500 pM50 nM

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