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GDC-0980 (Apitolisib, RG7422)


mTOR/PI3K Inhibitor

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Catalog No. A11023

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GDC-0980 5mg A11023-5

Regular Price: $60.00

Special Price: $48.00

GDC-0980 10mg A11023-10

Regular Price: $100.00

Special Price: $80.00

GDC-0980 50mg A11023-50

Regular Price: $350.00

Special Price: $280.00

GDC-0980 100mg A11023-100

Regular Price: $580.00

Special Price: $464.00

GDC-0980 (RG7422) 10mM * 1mL in DMSO A11023-10mM-D

Regular Price: $119.00

Special Price: $95.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.

GDC-0980 (Apitolisib, RG7422)

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Chemical Information

Catalog Num A11023
Actions Inhibitor
M. Wt 498.6
Formula C23H30N8O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1032754-93-0
Synonyms GDC0980
SMILES code CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[[email protected]](C)O
Chemical Name (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one

Biological Activity

GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.
p110α (Cell-free assay) p110δ (Cell-free assay) p110γ (Cell-free assay) mTOR (Cell-free assay) p110β (Cell-free assay)
5 nM7 nM14 nM17 nM(Ki app)27 nM


Solubility (25°C) * In vitro DMSO 20 mg/mL (40.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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