GSK1070916

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Aurora Kinase inhibitor

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Catalog No. A11168

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GSK1070916 5mg A11168-5
$90.00
GSK1070916 10mg A11168-10
$150.00
GSK1070916 50mg A11168-50
$400.00
GSK1070916 100mg A11168-100
$700.00
GSK1070916 10mM * 1mL in DMSO A11168-10mM-D
$100.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GSK1070916 is a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.

GSK1070916

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Chemical Information

Catalog Num A11168
Actions Inhibitor
M. Wt 507.63
Formula C30H33N7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 942918-07-2
Synonyms GSK-1070916
SMILES code CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C
Chemical Name N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea

Biological Activity

Description

GSK1070916 is a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.

Targets
Target Value
AuroraB-INCENPIC50: 3.5nM
AuroraC-INCENPIC50: 6.5nM
FLT1IC50: 42nM
Tie-2IC50: 59nM
SIKIC50: 70nM
FLT4IC50: 74nM
FGFR1IC50: 76nM
AuroraA-TPX2IC50: 1.1μM

Solubility

Solubility (25°C) * In vitro DMSO 102 mg/mL (200.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol 102 mg/mL (200.93 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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