GSK690693

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AKT inhibitor

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Catalog No. A11030

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GSK690693 10mg A11030-10

Regular Price: $120.00

Special Price: $96.00

GSK690693 25mg A11030-25

Regular Price: $220.00

Special Price: $176.00

GSK690693 50mg A11030-50

Regular Price: $360.00

Special Price: $288.00

GSK690693 100mg A11030-100

Regular Price: $600.00

Special Price: $480.00

GSK690693 10mM * 1mL in DMSO A11030-10mM-D

Regular Price: $75.00

Special Price: $60.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).

GSK690693

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Chemical Information

Catalog Num A11030
Actions Inhibitor
M. Wt 425.5
Formula C21H27N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 937174-76-0
Synonyms GSK-690693
SMILES code CCN1C2=C(C(=NC=C2OC[[email protected]]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
Chemical Name 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

Biological Activity

Description
GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
Targets
Target Value
Akt1IC50: 2nM
PKCηIC50: 2nM
PKCθIC50: 2nM
PrkXIC50: 5nM
Akt3IC50: 9nM
Akt2IC50: 13nM
PKCδIC50: 14nM
PKCβIC50: 19nM
PKCεIC50: 21nM
PKAIC50: 24nM
PKG1βIC50: 33nM

Solubility

Solubility (25°C) * In vitro DMSO 39 mg/mL (91.66 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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