IWR-1-endo

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Wnt inhibitor

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Catalog No. A12737

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
IWR-1-endo 10mg A12737-10

Regular Price: $70.00

Special Price: $56.00

IWR-1-endo 25mg A12737-25

Regular Price: $150.00

Special Price: $120.00

IWR-1-endo 50mg A12737-50

Regular Price: $250.00

Special Price: $200.00

IWR-1-endo 100mg A12737-100

Regular Price: $450.00

Special Price: $360.00

IWR-1-endo 10mM * 1mL in DMSO A12737-10mM-D

Regular Price: $88.00

Special Price: $70.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.

IWR-1-endo

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Chemical Information

Catalog Num A12737
Actions Inhibitor
M. Wt 409.44
Formula C25H19N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1127442-82-3
Synonyms N/A
SMILES code C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6
Chemical Name [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-H?exahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N?-8-quinolinylbenzamide

Biological Activity

Description
IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
Targets
Wnt (L-cells expressing Wnt3A)
180 nM

Solubility

Solubility (25°C)* In vitro DMSO 30 mg/mL (73.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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