β-catenin

Cat. No.

A11039

CAS No.

780757-88-2

ICG-001

ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) .

Cat. No.

A12737

CAS No.

1127442-82-3

IWR-1-endo

IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.

Cat. No.

A13795

CAS No.

108409-83-2

FH535

FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.

Cat. No.

A14381

CAS No.

1227637-23-1

BC2059

BC2059 is an orally bioavailable and potent beta-catenin inhibitor.

Cat. No.

A15856

CAS No.

1422253-38-0

Foscenvivint (PRI-724)

Synonyms: PRI 724

PRI-724 is the second-generation, potent and specific inhibitor of CBP/β-Catenin complex, and a modulator of the β-Catenin dependent canonical Wnt signaling pathway in cancer stem cells.

Cat. No.

A12208

CAS No.

84680-75-1

Astragaloside I

Synonyms: Astrasieversianin IV; Cyclosieversioside B

Astragaloside I is a Wnt/β-catenin activator known for its osteogenic properties. It promotes osteoblast differentiation by enhancing the Wnt/β-catenin signaling pathway. This compound is valuable for research focused on bone development, regeneration, and related signaling mechanisms in various biological systems.

Cat. No.

A13710

CAS No.

82-89-3

Prodigiosin

Synonyms: Prodigiosine

Prodigiosin (Prodigiosine) is a secondary metabolite of Symbiotic bacteria, with anti-fungal and anti-cancer activity.

Cat. No.

A13986

CAS No.

915759-45-4

WAY-316606

WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.

Cat. No.

A15773

CAS No.

671225-39-1

Cardiogenol C

Cardiogenol C is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.

Cat. No.

A16064

CAS No.

331001-62-8

IQ-1

IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling.

Cat. No.

A16198

CAS No.

1049741-55-0

Cardiogenol C HCl

Synonyms: Cardiogenol C

Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells.

Cat. No.

A16217

CAS No.

70-30-4

Hexachlorophene

Synonyms: Hexachlorofen

Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling.

Cat. No.

A16218

CAS No.

677331-12-3

iCRT 14

iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity).

Cat. No.

A16353

CAS No.

1956356-56-1

KYA1797K

KYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay).

Cat. No.

A16448

CAS No.

72-80-0

Chlorquinaldol

Chlorquinaldol is an antimicrobial agent used for local antisepsy.

Cat. No.

A16707

CAS No.

909089-13-0

SKL2001

SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.

Cat. No.

A16847

CAS No.

901751-47-1

iCRT3

iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays.

Cat. No.

A17004

CAS No.

686772-17-8

IWP-4

IWP-4 is a novel potent inhibitor of Wnt/β-catenin signaling.

Cat. No.

A17089

CAS No.

1799824-08-0

E-7386

E-7386 is an orally active CBP/beta-catenin modulator.

Cat. No.

A18381

CAS No.

537-98-4

(E)-Ferulic acid

(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.

Cat. No.

A18402

CAS No.

854847-61-3

HLY78

HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction.

Cat. No.

A18689

CAS No.

2305372-67-0

Wnt/β-catenin agonist 1

Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM.

Cat. No.

A18760

CAS No.

2204290-85-5

FzM1.8

FzM1.8 is an allosteric agonist of the Frizzled receptor FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K.

Cat. No.

A19287

CAS No.

2102672-22-8

DK419

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.

Cat. No.

A20284

CAS No.

292168-79-7

KY1220

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.