KPT185

CRM1 Inhibitor

0 Customer Reviews
Catalog No. A12975

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
KPT185 10mg A12975-10

Regular Price: $68.00

Special Price: $54.40

KPT185 25mg A12975-25

Regular Price: $100.00

Special Price: $80.00

KPT185 50mg A12975-50

Regular Price: $189.00

Special Price: $151.20

KPT185 100mg A12975-100

Regular Price: $320.00

Special Price: $256.00

KPT185 10mM * 1mL in DMSO A12975-10mM-D

Regular Price: $60.00

Special Price: $48.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

KPT185 is a selective CRM1 inhibitor. KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.

KPT185

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A12975
Actions Inhibitor
M. Wt 355.31
Formula C16H16F3N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1333151-73-7
Synonyms KPT 185, KPT-185
SMILES code CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F
Chemical Name (2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl Ester

Biological Activity

Description
KPT185 is a selective CRM1 inhibitor. KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.
Targets
CRM1

Solubility

Solubility (25°C)* In vitro DMSO 71 mg/mL (199.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol 71 mg/mL (199.82 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

View Related Products By Research Topics

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.


Keywords:buy KPT185 | KPT185 Supplier | purchase KPT185 | KPT185 cost | KPT185 manufacturer | order KPT185 | KPT185 distributor | buy 1333151-73-7| 1333151-73-7 Supplier | purchase 1333151-73-7 | 1333151-73-7 cost | 1333151-73-7 manufacturer | order 1333151-73-7 | 1333151-73-7 distributor