KU 0060648

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DNA-PK inhibitor

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Catalog No. A13224

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
KU 0060648 5mg A13224-5

Regular Price: $100.00

Special Price: $80.00

KU 0060648 10mg A13224-10

Regular Price: $180.00

Special Price: $144.00

KU 0060648 25mg A13224-25

Regular Price: $350.00

Special Price: $280.00

KU 0060648 50mg A13224-50

Regular Price: $600.00

Special Price: $480.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency.

KU 0060648

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Chemical Information

Catalog Num A13224
Actions Inhibitor
M. Wt 692.1
Formula C33H34N4O4S.3HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 881375-00-4
Synonyms KU0060648, KU-0060648
SMILES code CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7
Chemical Name 2-(4-Ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide trihydrochloride

Biological Activity

Description
KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency.

Solubility

Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water 0.4 mg/mL (0.68 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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