KW-2449

ON SALE

Aurora Inhibitor

0 Customer Reviews
Catalog No. A10508

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
KW-2449 10mg A10508-10

Regular Price: $50.00

Special Price: $42.50

KW-2449 50mg A10508-50

Regular Price: $220.00

Special Price: $187.00

KW-2449 100mg A10508-100

Regular Price: $400.00

Special Price: $340.00

KW-2449 200mg A10508-200

Regular Price: $680.00

Special Price: $578.00

KW-2449 10mM * 1mL in DMSO A10508-10mM-D

Regular Price: $76.00

Special Price: $64.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.

KW-2449

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A10508
Actions Inhibitor
M. Wt 332.4
Formula

C20H20N4O

Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1000669-72-6
Synonyms KW 2449, KW2449
SMILES code C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43
Chemical Name [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

Biological Activity

Description
KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
Targets
Target Value
FLT3(D835Y)IC50: 1nM
Abl(T315I)IC50: 4nM
FLT3IC50: 6.6nM
AblIC50: 14nM
FGFR1IC50: 36nM
AuroraAIC50: 48nM
JAK2IC50: 150nM
KitIC50: 300nM
SrcIC50: 400nM
PDGFRαIC50: 1.7μM

Solubility

Solubility (25°C) * In vitro DMSO 67 mg/mL (201.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol 67 mg/mL (201.56 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.


Keywords:buy KW-2449 | KW-2449 Supplier | purchase KW-2449 | KW-2449 cost | KW-2449 manufacturer | order KW-2449 | KW-2449 distributor | buy 1000669-72-6| 1000669-72-6 Supplier | purchase 1000669-72-6 | 1000669-72-6 cost | 1000669-72-6 manufacturer | order 1000669-72-6 | 1000669-72-6 distributor