MK-8745

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Aurora Kinase Inhibitor

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Catalog No. A13396

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
MK-8745 10mg A13396-10

Regular Price: $60.00

Special Price: $51.00

MK-8745 25mg A13396-25

Regular Price: $120.00

Special Price: $102.00

MK-8745 50mg A13396-50

Regular Price: $180.00

Special Price: $153.00

MK-8745 10mM * 1mL in DMSO A13396-10mM-D

Regular Price: $60.00

Special Price: $51.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.

MK-8745

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Chemical Information

Catalog Num A13396
Actions Inhibitor
M. Wt 431.91
Formula C20H19ClFN5OS
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 885325-71-3
Synonyms MK8745, MK 8745
SMILES code ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1
Chemical Name (3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone

Biological Activity

Description
MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Targets
Aurora A Aurora B
0.6 nM280 nM

Solubility

Solubility (25°C)* In vitro DMSO 86 mg/mL (199.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.31 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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