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- JM Sahni ,etc. Bromodomain and extraterminal protein inhibition blocks growth of triple-negative breast cancers through the suppression of Aurora kinases. Journal of Biological Chemistry, 2016, 291(45), 23756-23768.
- D Lessing ,etc. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proceedings of the National Academy of Sciences, 2016, 113(50):14366-14371..
|Solubility||DMSO>44mg/mL Water <1mg/mL Ethanol <1mg/mL|
|Storage||at -20°C 2 years|
|Chemical Name||4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d]benzazepin-2-yl]amino]-2-methoxybenzoic acid|
|MLN8237 (Alisertib) is a selective Aurora kinase A inhibitor with a median IC50 of 61 nM.|
|Solubility (25°C) *||In vitro||DMSO||27 mg/mL (52.03 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||15% Captisol||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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