Monomethyl auristatin E

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Catalog No. A12954

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Monomethyl auristatin E 5mg A12954-5

Regular Price: $190.00

Special Price: $161.50

Monomethyl auristatin E 10mg A12954-10

Regular Price: $300.00

Special Price: $255.00

Monomethyl auristatin E 25mg A12954-25

Regular Price: $500.00

Special Price: $425.00

Monomethyl auristatin E 50mg A12954-50

Regular Price: $850.00

Special Price: $722.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.

Monomethyl auristatin E

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Chemical Information

Catalog Num A12954
Actions Stimulator
M. Wt 717.98
Formula C39H67N5O7
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 474645-27-7
Synonyms Monomethylauristatin E, MMAE
SMILES code CC[[email protected]](C)[[email protected]@H]([[email protected]@H](CC(=O)N1CCC[[email protected]]1[[email protected]@H]([[email protected]@H](C)C(=O)N[[email protected]](C)[[email protected]](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](C(C)C)NC
Chemical Name N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

Biological Activity

Description
Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.

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