Netupitant

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NK1 receptor antagonist

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Catalog No. A14428

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Netupitant 5mg A14428-5

Regular Price: $40.00

Special Price: $36.00

Netupitant 10mg A14428-10

Regular Price: $70.00

Special Price: $63.00

Netupitant 25mg A14428-25

Regular Price: $150.00

Special Price: $135.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).

Netupitant

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Chemical Information

Catalog Num A14428
Actions Antagonist
M. Wt 578.59
Formula C30H32F6N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 290297-26-6
Synonyms D05152, AG-E-94200
SMILES code CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C
Chemical Name 2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide

Biological Activity

Description
Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).
Targets
neurokinin 1 receptor

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